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Do the job by Some others, together with Dickey, has revealed that upsized mucin secretion while in the airways functions in A great deal the identical way, involving analogous vesicles (full of mucin in place of neurotransmitters) and synaptotagmin and collaborating proteins.
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What’s extra, the freshly secreted mucus frequently incorporates a better-than-normal mucin information. The thereby thickened mucus can congeal into rubbery pads, or plaques, stifling gasoline Trade within the lungs and impeding airway cilia’s upward pumping of mucus-entrapped pathogens.
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Brunger’s and Dickey’s teams created a little protein snippet, or peptide, known as SP9, that blocked synaptotagmin’s calcium-triggered interaction with its cooperating proteins in mice.
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